Free Lille Score Calculator

Lille Score Calculator: A Prognostic Tool for Alcoholic Hepatitis

The Lille score calculator (also called the Lille model or Lille survival score) is a validated clinical index that estimates the six-month survival probability for patients diagnosed with severe alcoholic hepatitis who have initiated corticosteroid therapy. By combining key laboratory markers and age, this free online calculator produces a numerical score that helps clinicians judge whether the patient is responding to steroids or whether alternative interventions should be considered.

Understanding Alcoholic Hepatitis and the Need for Scoring

Alcoholic hepatitis is an acute inflammatory liver condition triggered by chronic alcohol overuse. It can progress rapidly to liver failure or lead to cirrhosis over time. The Lille alcoholic hepatitis score was specifically designed to assess prognosis after one week of steroid treatment, allowing doctors to decide whether to continue therapy, attempt salvage treatments, or prepare for transplantation. Several other liver disease scores exist, such as the Child‑Pugh score and Maddrey’s discriminant function, but the Lille model is unique because it incorporates the change in bilirubin during the first week of treatment.

Variables Required by the Lille Model

The calculator requires six inputs, five obtained on admission (day 0) and one on day 7. The tool accepts multiple common units and performs automatic conversions.

Parameter	Collection Day	Common Units	Conversion Note
Age	Day 0	years	–
Prothrombin Time (PT)	Day 0	seconds	–
Albumin	Day 0	g/dL or g/L	1 g/dL = 10 g/L
Bilirubin	Day 0 and Day 7	mg/dL or µmol/L	1 mg/dL = 17.1 µmol/L
Creatinine	Day 0	mg/dL or µmol/L	1 mg/dL = 88.4 µmol/L

From the creatinine value a binary renal insufficiency indicator is derived:

• Creatinine > 1.3 mg/dL (115 µmol/L) → renal insufficiency = 1
• Creatinine ≤ 1.3 mg/dL (115 µmol/L) → renal insufficiency = 0

The Lille Model Formula

The score is computed in two stages. First, an intermediate variable $R$ is obtained from the logistic regression equation:

$$\begin{aligned} R = &\; 3.19 \\ &- 0.101 \times \text{Age (years)} \\ &+ 0.147 \times \text{Albumin (g/L)} \\ &+ 0.0165 \times (\text{Bilirubin}_{\text{day 7}} - \text{Bilirubin}_{\text{day 0}}) \\ &- 0.206 \times \text{Renal insufficiency} \\ &- 0.0065 \times \text{Bilirubin}_{\text{day 0}} \\ &- 0.0096 \times \text{PT (seconds)} \end{aligned}$$

The final Lille score is then given by the logistic transformation:

$$\text{Lille score} = \frac{\exp(-R)}{1 + \exp(-R)}$$

The result ranges from 0 to 1. A score below 0.45 generally indicates a favorable response to steroids and a better six‑month survival outlook, while a score of 0.45 or higher points to a poor response, suggesting that continued corticosteroid therapy may not be beneficial.

Interpreting the Results

When the necessary data are entered, the Lille score calculator outputs both the score and the corresponding survival prediction. This information supports risk stratification and can help guide decisions such as early referral for liver transplantation or initiation of rescue therapies. Lower scores are associated with a higher likelihood of surviving six months, whereas higher scores indicate a greater risk of mortality.

Important Disclaimer

This tool is designed to be accurate and reliable, but it cannot replace a thorough clinical assessment by a qualified physician. The Lille score should always be interpreted together with the patient’s full history, imaging findings, and other diagnostic data.